Where is respiratory epithelium




















Airway epithelial differentiation and mucociliary clearance. You, Y. Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells. Griggs, T. Rhinovirus C targets ciliated airway epithelial cells.

Bochkov, Y. Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.

Jackson, D. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Tamashiro, E. Cigarette smoke exposure impairs respiratory epithelial ciliogenesis. Allergy 23 , — Exhaustion of airway basal progenitor cells in early and established chronic obstructive pulmonary disease.

Rajavelu, P. Park, K. SPDEF regulates goblet cell hyperplasia in the airway epithelium. Chen, G. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity. Korfhagen, T. SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia.

SAM-pointed domain ETS factor mediates epithelial cell—intrinsic innate immune signaling during airway mucous metaplasia. Evans, C. The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Roy, M. Muc5b is required for airway defence. Feyrter, F. CAS Google Scholar. Kuo Christin, S. Formation of a neurosensory organ by epithelial. Cell Slithering. Cell , — Chapter Three - Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells.

In Current Topics in Developmental Biology , vol. Branchfield, K. Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science , — Number and proliferation of neuroendocrine cells in normal human airway epithelium.

Hockman, D. Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. Reynolds, S. Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration. Cutz, E. Pulmonary neuroendocrine cell system in pediatric lung disease—recent advances. Ouadah, Y. Rare pulmonary neuroendocrine cells are stem cells regulated by Rb, p53, and Notch.

Cell , — Song, H. Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis.

Recent advances and contraversies on the role of pulmonary neuroepithelial bodies as airway sensors. Cell Dev. Fu, H. Calcitonin gene-related peptide protects type II alveolar epithelial cells from hyperoxia-induced DNA damage and cell death. Gu, X. Chemosensory functions for pulmonary neuroendocrine cells. Atanasova, K. Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis.

Qin, L. Blood , — Chen, C. Cell Biochem. Fabre, A. Modulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice. Sato, E. Histamine and serotonin stimulate eotaxin production by a human lung fibroblast cell line.

Allergy Immunol. Goolaerts, A. Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel. Gaete, P. Mapp, P. A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivo. Yule, K. Migration of 3T3 and lung fibroblasts in response to calcitonin gene-related peptide and bombesin. Lung Res. Kawanami, Y. Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells.

Subramaniam, M. Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia. Tan, Y. Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation. Peptides 27 , — Liu, H. Activation of bombesin receptor subtype-3 promotes antigen-presenting action in human bronchial epithelial cells. Sui, P. Pulmonary neuroendocrine cells amplify allergic asthma responses. Science , eaan Belvisi, M.

Bombesin-induced bronchoconstriction in the guinea pig: mode of action. Jankala, E. On the bronchoconstrictor effect of serotonin. Bronchographic studies on rabbits and guinea-pigs. Brain, S. Calcitonin gene-related peptide is a potent vasodilator. Nature , 54—56 Bombesin-like peptides and mast cell responses. Kuo, H. Capsaicin and sensory neuropeptide stimulation of goblet cell secretion in guinea-pig trachea. Webber, S. The effects of calcitonin gene-related peptide on submucosal gland secretion and epithelial albumin transport in the ferret trachea in vitro.

Herr, N. The effects of serotonin in immune cells. Ye, Y. Dermatophagoides pteronyssinus 2 regulates nerve growth factor release to induce airway inflammation via a reactive oxygen species-dependent pathway. Hahn, C. Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation.

Pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome: potential markers of airway chemoreceptor dysfunction.

Alshehri, M. Hyperplasia of pulmonary neuroendocrine cells in a case of childhood pulmonary emphysema. Characterization of the cell of origin for small cell lung cancer. Cell Cycle 10 , — Sutherland Kate, D. Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung. Cancer Cell 19 , — Howitt, M. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Gerbe, F. Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites.

Jarvi, O. On the cellular structures of the epithelial invasions in the glandular stomach of mice caused by intramural application of methylcholantren. Acta Pathol. Microbiol Scand. Rhodin, J. Electron microscopy of the tracheal ciliated mucosa in rat. Mikroskopische Anat. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. Cell Biol. Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin.

USA 93 , — Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells. Fletcher, R. Deconstructing olfactory stem cell trajectories at single-cell resolution. Cell Stem Cell 20 , — Krasteva, G. Cholinergic chemosensory cells in the auditory tube. Wiederhold, S. A novel cholinergic epithelial cell with chemosensory traits in the murine conjunctiva.

Luciano, L. The brush cells of the common bile duct of the rat. Cell Tissue Res. Presence of brush cells in the mouse gallbladder. Nevalainen, T. Ultrastructural characteristics of tuft cells in mouse gallbladder epithelium. Cells Tissues Organs 98 , — Deckmann, K. Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes. Chemosensory epithelial cells in the urethra: sentinels of the urinary tract.

Histochemistry Cell Biol. Bornstein, C. Single-cell mapping of the thymic stroma identifies ILproducing tuft epithelial cells. Miller, C. Thymic tuft cells promote an ILenriched medulla and shape thymocyte development. Schneider, C. Regulation of immune responses by tuft cells. Ting, H. The immune function of tuft cells at gut mucosal surfaces and beyond.

Barham, H. Solitary chemosensory cells and bitter taste receptor signaling in human sinonasal mucosa. Forum Allergy Rhinol. Sharma, P. Bitter taste receptor agonists mitigate features of allergic asthma in mice. Matsumoto, I. Skn-1a Pou2f3 specifies taste receptor cell lineage. Morroni, M. Brush cells in the human duodenojejunal junction: an ultrastructural study.

Tuft cells—systemically dispersed sensory epithelia integrating immune and neural circuitry. Tizzano, M. Expression of taste receptors in solitary chemosensory cells of rodent airways.

BMC Pulm. Evidence of solitary chemosensory cells in a large mammal: the diffuse chemosensory system in Bos taurus airways. Haber, A. A single-cell survey of the small intestinal epithelium. Rane, C. Development of solitary chemosensory cells in the distal lung after severe influenza injury. DelGiorno, K. Identification and manipulation of biliary metaplasia in pancreatic tumors.

Gastroenterology , — Westphalen, C. Long-lived intestinal tuft cells serve as colon cancer-initiating cells. Qu, D. Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells.

Bailey, J. DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer. Gastroenterology , — Hayakawa, Y. Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling. Cancer Cell 31 , 21—34 Huang, Y. POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes Dev. Jonz, M. Epithelial mitochondria-rich cells and associated innervation in adult and developing zebrafish.

Quigley, I. Specification of ion transport cells in the Xenopus larval skin. Chen, Y. Zebrafish Klf4 maintains the ionocyte progenitor population by regulating epidermal stem cell proliferation and lateral inhibition.

PLoS Genet. Miah, K. Emerging gene therapies for cystic fibrosis. Expert Rev. Riordan, J. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science , Anderson, M. Nucleoside triphosphates are required to open the CFTR chloride channel. Cell 67 , — Choi, J. Nature , 94—97 Kimura, S. Molecular insights into the mechanisms of M-cell differentiation and transcytosis in the mucosa-associated lymphoid tissues.

Fujimura, Y. Evidence of M cells as portals of entry for antigens in the nasopharyngeal lymphoid tissue of humans. Virchows Arch. Kim, D. The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. Nair Vidhya, R. Microfold cells actively translocate Mycobacterium tuberculosis to initiate infection. Khan, H. Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis.

Lambrecht, B. The airway epithelium in asthma. Dudas, P. The role of the epithelium in chronic inflammatory airway disease. Therapeutics 25 , — Wang, J. Wei, H. Suppression of interferon lambda signaling by SOCS-1 results in their excessive production during influenza virus infection. PLoS Pathog. Hillyer, P. Differential responses by human respiratory epithelial cell lines to respiratory syncytial virus reflect distinct patterns of infection control.

Wang, Q. Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. Slater, L. Xander, N. Schneider, D. Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease. Parkin, J. An overview of the immune system. Hiemstra, P. The innate immune function of airway epithelial cells in inflammatory lung disease. Proud, D. Epithelial cells and airway diseases.

Hannila, S. Neuroscientist 21 , — Sahl, H. Mammalian defensins: structures and mechanism of antibiotic activity. Bals, R. Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Niyonsaba, F. Glaser, L. Airway epithelial derived cytokines and chemokines and their role in the immune response to respiratory syncytial virus infection. Pathogens 8 , McNamara, P. Respiratory syncytial virus infection of airway epithelial cells, in vivo and in vitro, supports pulmonary antibody responses by inducing expression of the B cell differentiation factor BAFF.

Thorax 68 , 76—81 Guillot, L. Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. Le Goffic, R. Sykes, A. Meylan, E. Intracellular pattern recognition receptors in the host response. Nature , 39—44 Benam, K. How the respiratory epithelium senses and reacts to influenza virus. Allen, I.

Immunity 30 , — Blanco-Melo, D. Cell , — e Vanderheiden, A. Clemans, D. Induction of proinflammatory cytokines from human respiratory epithelial cells after stimulation by nontypeable Haemophilus influenzae. Soong, G. TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cells.

Gomez, M. Airway epithelial cell signaling in response to bacterial pathogens. Bello-Irizarry, S. The alveolar epithelial cell chemokine response to pneumocystis requires adaptor molecule MyD88 and interleukin-1 receptor but not toll-like receptor 2 or 4. Perez-Nazario, N. Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis. Jhingran, A. Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection.

Beisswenger, C. Aspergillus fumigatus conidia induce interferon-beta signalling in respiratory epithelial cells. Snelgrove, R. A critical function for CD in lung immune homeostasis and the severity of influenza infection. Hussell, T. Alveolar macrophages: plasticity in a tissue-specific context. Jiang-Shieh, Y. Distribution and expression of CD in the rat respiratory system under normal and endotoxin-induced pathological conditions.

Zhang, S. Molecular mechanisms of CD inhibition of mast cell activation. Mihrshahi, R. Jamieson, K. Rhinovirus and bacteria synergistically induce ILC release from human airway epithelial cells to promote neutrophil recruitment. Holgate, S.

Epithelial-mesenchymal interactions in the pathogenesis of asthma. Hammad, H. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Millien, V. Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4.

Lloyd, C. Epithelial cytokines and pulmonary allergic inflammation. Fahy, J. Type 2 inflammation in asthma—present in most, absent in many. Bartemes, K. Dynamic role of epithelium-derived cytokines in asthma. Mitchell, P.

Biologics and the lung: TSLP and other epithelial cell-derived cytokines in asthma. Hurst, S. Fort, M. Immunity 15 , — Schmitz, J. IL, an interleukinlike cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23 , — Soumelis, V. Human epithelial cells trigger dendritic cell—mediated allergic inflammation by producing TSLP.

Kool, M. An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity 34 , — Idzko, M. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells.

The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation. Allergy 65 , — Nathan, A. Electrogenic chloride secretion by mammalian colon. Degnan, K. Karnaky, and J. Active chloride transport in the in vitro opercular skin of a teleost Fundulus heteroclitus , a gill—like epithelium rich in chloride cells. London : — Machen, T. Membrane resistances and electromotive forces.

Schultz, S. Frizzell, and H. Active sodium transport and the electrophysiology of rabbit colon. Inhibition of chloride secretion by furosemide in canine tracheal epithelium. Davis, B. Marin, J. Yee, and J. Effect of substance P on ion transport by tracheal mucosa.

Intracellular chloride activities in canine tracheal epithelium: Direct evidence for sodium-coupled intracellular chloride accumulation in a chloride secreting epithelium. Spokes, J. Epstein, and F. Desert I si. Smith, E. Vosburgh, and M. Coupled sodium-chloride influx across brush border of flounder intestine. Geek, P. Pietrzyk, B. Burckhardt, B. Pfeiffer, and E. Acta : — Liedtke, C. Mechanism of Cl - translocation across small intestinal brush-border membrane. Cabantchik, Z. Membrane proteins related to anion permeability of human red blood cells.

Shorofsky, S. Field, and H. Electrophysiology of Cl secretion in canine trachea. Evidence for a basolateral membrane potassium conductance in canine tracheal epithelium.

Changes in intracellular K activities after stimulation of CI secretion in canine tracheal epithelium.

Chest 81 : 5S. Westenfelder, C. Earnest, and F. Eaton, D. Effects of barium on the potassium conductance of squid axon. Kirk, K. Halm, and D. Active sodium transport by turtle colon via an electrogenic Na-K exchange pump. Nature London : — Standen, N. A potential-and time-dependent blockade of inward rectification in frog skeletal muscle fibres by barium and strontium ions.

Barium inhibition of basolateral membrane potassium conductance in tracheal epithelium. Higgins, J. Gebler, and E. Electrical properties of amphibian urinary bladder. The cell potential profile in Necturus maculosa. Pfluegers Arch. The role of calcium in the potassium permeability of human erythrocytes. Acta Physiol. Koefoed-Johnsen, V. The nature of the frog skin potential.

Ion transport by dog tracheal epithelium. Smith, M. Fromm, and R. Crypts are the site of intestinal fluid and electrolyte secretion. Science : — Stutts, and J.

Regional differences in bioelectric properties and ion flow in excised canine airways. Physiol 51 : — Lane, R. Gordon, and E. Ultrastructure of rat tracheal epithelium. Lung : — Inoue, S. Freeze-etch study of the tracheal epithelium of normal guinea pigs with particular reference to intercellular junctions. Schneeberger, E. Heterogeneity of tight junction morphology in extrapulmonary and intrapulmonary airways of the rat.

Regional effects of autonomic agents on ion transport across excised canine airways. Legris, G. Will, and U. Inhibition of amiloride-sensitive sodium conductance by indoleamines. USA 79 : — Nielson, D. Goerke, and J. Alveolar subphase pH in the lungs of anesthetized rabbits. USA 78 : — Haies, D. Gil, and E. Morphometric study of rat lung cells. Numerical and dimensional characteristics of parenchymal cell population. Structural basis for some permeability properties of the air blood barrier.

Utilization of alveolar epithelial type II cells for the study of pulmonary surfactant. Mason, R. Synthesis of saturated phosphatidylcholine and phosphatidylglycerol by freshly isolated rat alveolar type II cells. Substructure of intercellular junctions in freeze-fractured alveolar-capillary membranes of mouse lung. Ultrastructural basis for alveolar-capillary permeability to protein. Ciba Found. The influence of intravascular fluid volume on the permeability of newborn and adult mouse lungs to ultrastructural protein tracers.

Schneeberger-Keeley, E. The ultrastructural basis of alveolar-capillary membrane permeability to peroxidase used as a tracer.

Taylor, A. Guyton, and V. Permeability of the alveolar membrane to solutes. Estimation of equivalent pore radii of pulmonary capillary and alveolar membranes. Theodore, J. Robin, R. Gaudio, and J. Transalveolar transport of large polar solutes sucrose, inulin, and dextran. Egan, E. Nelson, andR.

Lung inflation and alveolar permeability to non-electrolytes in the adult sheep in vivo. Matthay, M. Landolt, andN. Differential liquid and protein clearance from the alveoli of anesthetized sheep. Widdicombe, and N. Clearance of alveolar fluid in sheep may involve an active ion transport process. Gatzy, J. Bioelectric properties of the isolated amphibian lung. Ion transport across the excised bullfrog lung. Crandall, E. Transport of water and solutes across bullfrog alveolar epithelium.

Goodman, B. Dome formation in primary cultured monolayers of alveolar epithelial cells. Williams, J. Widdicombe, M. Sanders, D. Misfeldt, and L. Transepithelial transport by pulmonary alveolar type-II cells in primary culture.

Pulmonary alveolar epithelial cells form domes in primary culture. Dobbs, L. Mason, M. Williams, B. Benson, and K. Secretion of surfactant by primary cultures of al-veolar type II cells isolated from rats.

Misfeldt, D. Hamamoto, and D. Transepithelial transport in cell culture. USA 73 : — Cereijido, M. Robbins, W. Dolan, C. Rotunno, and D. Polarized monolayers formed by epithelial cells on a permeable and translucent support. Handler, J. Perkins, and J. Studies of renal cell function using cell culture techniques. Fleischer, and E. Effects of metabolic inhibitors on dome formation by cultured alveolar epithelial cells.

Evidence for sodium transport by cultured alveolar epithelial cells. Alcorn, D. Adamson, T. Lambert, J. Maloney, B. Ritchie, and P. Morphological effects of chronic tracheal ligation and drainage in the fetal lamb lung.

Griscom, N. Harris, M. Wohl, G. Vawter, and A. Fluid-filled lung due to airway obstruction in the newborn. Pediatrics 43 : —



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